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We recommend booking a stay with free cancellation in case your plans change.
Guest room
You have until December 21, 2024 to cancel this reservation without penalty.
USD $ 153 /nt
You have until December 21, 2024 to cancel this reservation without penalty.
You have until December 21, 2024 to cancel this reservation without penalty.
Deluxe room, 1 King bed
USD $ 153 /nt
You have until December 21, 2024 to cancel this reservation without penalty.
You have until December 21, 2024 to cancel this reservation without penalty.
Deluxe room, 2 Double or Full beds, 1 Queen bed
USD $ 216 /nt
You have until December 21, 2024 to cancel this reservation without penalty.
Deluxe room, 2 Double or Full beds, 1 Queen bed
USD $ 216 /nt
You have until December 21, 2024 to cancel this reservation without penalty.
Luxury room, 1 Double or Full bed, 1 Queen bed
USD $ 225 /nt
You have until December 21, 2024 to cancel this reservation without penalty.
Deluxe room, 2 Double or Full beds, 1 Queen bed
USD $ 225 /nt
You have until December 21, 2024 to cancel this reservation without penalty.
Corner room, 1 King bed
You have until December 21, 2024 to cancel this reservation without penalty.
You have until December 21, 2024 to cancel this reservation without penalty.
Deluxe room, 1 King bed
You have until December 21, 2024 to cancel this reservation without penalty.
Deluxe room, 1 King bed
You have until December 21, 2024 to cancel this reservation without penalty.
Corner room, 1 King bed
You have until December 21, 2024 to cancel this reservation without penalty.
1 King bed
You have until December 21, 2024 to cancel this reservation without penalty.
1 King bed
You have until December 21, 2024 to cancel this reservation without penalty.
Luxury room, 1 King bed
You have until December 21, 2024 to cancel this reservation without penalty.
Please note, room photos and descriptions are representative of the room category. Actual rooms may vary from what is shown. Upgrades, early check-in, and late check-out are based on availability.
21c Museum Hotels reimagines a historic St. Louis fixture: the 10-story, Renaissance Revival-style YMCA building. Located in the heart of downtown St. Louis, and a short walk from the City Museum and CITYPARK stadium, 21c Museum Hotel St. Louis includes a 173-room boutique hotel, contemporary art museum, Idol Wolf restaurant, Good Press café, and Locust Street Athletic and Swim Club, a full-service wellness center. With more than 14,000 square feet of exhibition and meeting & event space seamlessly integrated into all areas of the property, there are opportunities to discover contemporary art around every corner.
21c Museum Hotel St. Louis
1528 Locust Street
Saint Louis, Missouri
63103
Nearest Airport: STL
Kevin and Colin made my trip amazing. It was only me and my two children they made sure we were safe. However in my room the telephone did not work. The bellman was amazing! Highlight of my stay. I also enjoyed the complementary beverage nice way to wind down with children
Leonka C
We had an event there and Kevin at valet was incredible! He helped us unload our cars and take them to the event space. He went out of his way to make sure we had everything we needed and were set up in the space before he left. Thanks Kevin Huge shoutout!!
Aly H
An elegant hotel with a lovely pool and fitness center. I spent four nights there and received outstanding service. The rooms were inviting, and the bed was comfortable. The bar was beautiful, and the art gallery is so cool. I will definitely be back.
Raquel M
Terrible. We booked the “corner king.” From the photos on the website, it had a “sitting” area with a couch. Nope. Got to the room, and it’s a table with one chair and a stool. Seriously. Called down to complain, and were told that some of the “corner kings” have this configuration. BULL. Typical bait and switch. Also, the blower on the HVAC is so loud you really won’t believe it. We couldn’t hear the tv over it. The neighborhood is sketchy, so don’t plan to do a lot of walking around. Stay anywhere but here. Can’t believe this is a 21C property. What a joke!
veritas71 - Memphis, Tennessee
Kevin at the valet was so kind and helpful! He provided such wonderful assistance. He also made sure to tell us about the art gallery in the restaurant so we wouldn’t miss out on it. Would definitely recommend coming to both the restaurant and museum.
Ericka T
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