21c Museum Hotel St. Louis

Saint Louis, Missouri

8.5 Deluxe

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Choose Your Room

We recommend booking a stay with free cancellation in case your plans change.

S2Q
Guest room, at 21c Museum Hotel St. Louis
Room Image Coming Soon

Guest room

  • Uniquely abc up to 20 off bar Bunk room

USD $ 149 /nt

Limited availability.

BEST FLEXIBLE RATE

You have until February 17, 2025 to cancel this reservation without penalty.

USD $149 /nt
$521 for 3 nights
includes taxes & fees
Price breakdown

D1K
Deluxe room, 1 King bed, at 21c Museum Hotel St. Louis
Room Image Coming Soon

Deluxe room, 1 King bed

  • Uniquely abc up to 20 off bar deluxe King accessible
  • Accessible room

  • • Full Breakfast for up to two guests
  • • $50 USD Food & Beverage Credit, once per stay
  • • The following amenities are subject to availability at the time of check-in/departure:Early Check-In

You have until February 17, 2025 to cancel this reservation without penalty.

USD $177 /nt
$618 for 3 nights
includes taxes & fees
Price breakdown

BEST FLEXIBLE RATE

You have until February 17, 2025 to cancel this reservation without penalty.

USD $157 /nt
$549 for 3 nights
includes taxes & fees
Price breakdown

A1K
Deluxe room, 1 King bed, at 21c Museum Hotel St. Louis
Room Image Coming Soon

Deluxe room, 1 King bed

  • Uniquely abc up to 20 off bar deluxe King

  • • Full Breakfast for up to two guests
  • • $50 USD Food & Beverage Credit, once per stay
  • • The following amenities are subject to availability at the time of check-in/departure:Early Check-In

You have until February 17, 2025 to cancel this reservation without penalty.

USD $177 /nt
$618 for 3 nights
includes taxes & fees
Price breakdown

BEST FLEXIBLE RATE

You have until February 17, 2025 to cancel this reservation without penalty.

USD $157 /nt
$549 for 3 nights
includes taxes & fees
Price breakdown

B2Q
Deluxe room, 2 Double or Full beds, 1 Queen bed, at 21c Museum Hotel St. Louis
Room Image Coming Soon

Deluxe room, 2 Double or Full beds, 1 Queen bed

  • Deluxe Double Queen accessible
  • Accessible room

  • • Full Breakfast for up to two guests
  • • $50 USD Food & Beverage Credit, once per stay
  • • The following amenities are subject to availability at the time of check-in/departure:Early Check-In

You have until February 17, 2025 to cancel this reservation without penalty.

USD $186 /nt
$649 for 3 nights
includes taxes & fees
Price breakdown

A2Q
Deluxe room, 2 Double or Full beds, 1 Queen bed, at 21c Museum Hotel St. Louis
Room Image Coming Soon

Deluxe room, 2 Double or Full beds, 1 Queen bed

  • Deluxe Double Queen

  • • Full Breakfast for up to two guests
  • • $50 USD Food & Beverage Credit, once per stay
  • • The following amenities are subject to availability at the time of check-in/departure:Early Check-In

You have until February 17, 2025 to cancel this reservation without penalty.

USD $186 /nt
$649 for 3 nights
includes taxes & fees
Price breakdown

E2Q
Deluxe room, 2 Double or Full beds, 1 Queen bed, at 21c Museum Hotel St. Louis
Room Image Coming Soon

Deluxe room, 2 Double or Full beds, 1 Queen bed

  • Deluxe Double Queen roll in shower
  • Accessible room

  • • Full Breakfast for up to two guests
  • • $50 USD Food & Beverage Credit, once per stay
  • • The following amenities are subject to availability at the time of check-in/departure:Early Check-In

You have until February 17, 2025 to cancel this reservation without penalty.

USD $195 /nt
$681 for 3 nights
includes taxes & fees
Price breakdown

D2Q
Luxury room, 1 Double or Full bed, 1 Queen bed, at 21c Museum Hotel St. Louis
Room Image Coming Soon

Luxury room, 1 Double or Full bed, 1 Queen bed

  • Luxury Double Queen

  • • Full Breakfast for up to two guests
  • • $50 USD Food & Beverage Credit, once per stay
  • • The following amenities are subject to availability at the time of check-in/departure:Early Check-In

You have until February 17, 2025 to cancel this reservation without penalty.

USD $195 /nt
$681 for 3 nights
includes taxes & fees
Price breakdown

B1K
Corner room, 1 King bed, at 21c Museum Hotel St. Louis
Room Image Coming Soon

Corner room, 1 King bed

  • Corner King

USD $ 206 /nt

Limited availability.

BEST FLEXIBLE RATE

You have until February 17, 2025 to cancel this reservation without penalty.

USD $206 /nt
$721 for 3 nights
includes taxes & fees
Price breakdown

P2Q
Loft, 1 Double or Full bed, 1 Queen bed, at 21c Museum Hotel St. Louis
Room Image Coming Soon

Loft, 1 Double or Full bed, 1 Queen bed

  • Loft Double Queen
  • Loft

USD $ 226 /nt

Limited availability.

BEST FLEXIBLE RATE

You have until February 17, 2025 to cancel this reservation without penalty.

USD $226 /nt
$792 for 3 nights
includes taxes & fees
Price breakdown

E1K
Deluxe room, 1 King bed, at 21c Museum Hotel St. Louis
Room Image Coming Soon

Deluxe room, 1 King bed

  • Deluxe King suite accessible roll in shower

USD $ 309 /nt

Limited availability.

BEST FLEXIBLE RATE

You have until February 17, 2025 to cancel this reservation without penalty.

USD $309 /nt
$1,084 for 3 nights
includes taxes & fees
Price breakdown

S1K
Deluxe room, 1 King bed, at 21c Museum Hotel St. Louis
Room Image Coming Soon

Deluxe room, 1 King bed

  • Deluxe King suite

USD $ 309 /nt

Limited availability.

BEST FLEXIBLE RATE

You have until February 17, 2025 to cancel this reservation without penalty.

USD $309 /nt
$1,084 for 3 nights
includes taxes & fees
Price breakdown

J1K
Corner room, 1 King bed, at 21c Museum Hotel St. Louis
Room Image Coming Soon

Corner room, 1 King bed

  • Corner King suite

USD $ 409 /nt

Limited availability.

BEST FLEXIBLE RATE

You have until February 17, 2025 to cancel this reservation without penalty.

USD $409 /nt
$1,435 for 3 nights
includes taxes & fees
Price breakdown

T1K
Luxury room, 1 King bed, at 21c Museum Hotel St. Louis
Room Image Coming Soon

Luxury room, 1 King bed

  • Luxury King suite

USD $ 509 /nt

Limited availability.

BEST FLEXIBLE RATE

You have until February 17, 2025 to cancel this reservation without penalty.

USD $509 /nt
$1,786 for 3 nights
includes taxes & fees
Price breakdown

P1K
1 King bed, at 21c Museum Hotel St. Louis
Room Image Coming Soon

1 King bed

  • Library King suite

USD $ 509 /nt

Limited availability.

BEST FLEXIBLE RATE

You have until February 17, 2025 to cancel this reservation without penalty.

USD $509 /nt
$1,786 for 3 nights
includes taxes & fees
Price breakdown

V1K
1 King bed, at 21c Museum Hotel St. Louis
Room Image Coming Soon

1 King bed

  • 21c King suite

USD $ 626 /nt

Limited availability.

BEST FLEXIBLE RATE

You have until February 17, 2025 to cancel this reservation without penalty.

USD $626 /nt
$2,195 for 3 nights
includes taxes & fees
Price breakdown

Please note, room photos and descriptions are representative of the room category. Actual rooms may vary from what is shown. Upgrades, early check-in, and late check-out are based on availability.

About the Hotel

21c Museum Hotels reimagines a historic St. Louis fixture: the 10-story, Renaissance Revival-style YMCA building. Located in the heart of downtown St. Louis, and a short walk from the City Museum and CITYPARK stadium, 21c Museum Hotel St. Louis includes a 173-room boutique hotel, contemporary art museum, Idol Wolf restaurant, Good Press café, and Locust Street Athletic and Swim Club, a full-service wellness center. With more than 14,000 square feet of exhibition and meeting & event space seamlessly integrated into all areas of the property, there are opportunities to discover contemporary art around every corner.

Location

21c Museum Hotel St. Louis
1528 Locust Street
Saint Louis, Missouri 63103

Nearest Airport: STL

Features and Amenities

  • General Information
  • Pet Friendly
  • Dining
  • Cafe
  • Bar & Lounge
  • On-Site Amenities
  • Pool
  • Spa Services
  • Laundry Service
  • Fitness Center
  • WiFi
  • 24-Hour Front Desk
  • In-Room Amenities
  • Air Conditioning
  • Hair Dryers
  • Flat-Screen Televisions
  • Coffee & Tea Facilities
  • Blackout Curtains
  • Business
  • Business Center/Services
  • Nearby
  • Museums
  • Interests
  • Hotels
  • Signature Perks

Reviews for 21c Museum Hotel St. Louis

Overall fantastic short stay!

TripAdvisor Traveler Review Rating Reviewed 2 weeks ago

Everything about this cool hotel was terrific: Staff, rooms, art, pool, bar! A great vibe for sure! I especially want to compliment the valets, Kevin and Dello! They were great guys and so helpful! They greeted us with a very pleasant personality and warm smile! Kudos to both of them!!

Randi M - Springfield, United States


Service was lacking to say the least.

TripAdvisor Traveler Review Rating Reviewed 3 weeks ago

The hotel as a whole is great. The lobby, the gallery, the bar did not disappoint. The problem we had was with the service. It started with the check in. I was traveling with three kids and I asked the person checking us in where I could find something casual for dinner within a safe walking distance and he recommended the hotel restaurant which looked great but casual or for kids. He then said “I don’t know. I haven’t lived here in 6 years.” No big deal, I have Google. When we went to our room there was a dirty room service tray right outside our door. We found a place to eat (Rosalita’s) and when we got back we ordered 4 desserts (including ice cream) from room service. They gave us one fork and one knife. I called and they brought us a bunch of plastic forks. While getting ready for bed I realized there were no face-clothes, none. The next morning when the 4 of us start showering we realize there were 2 bath towels. I called the front desk and requested 6 more and explained there were 4 of us and we were on a tight schedule for a flight. They never came. We continued to get ready using the same 2 towels. After about 30 min. I called again and eventually they brought 3 towels. When we checked out I felt like I should say something to the front desk and when I did and I got a half-hearted “sorry” and then a blank stare. He could not have cared less.

I6118JHdaniellem - Deerfield Beach, Florida


5 star

TripAdvisor Traveler Review Rating Reviewed 3 weeks ago

Great stay room very clean and kevin was a great valet guy the bar and food was very good and the museum was awesome we would recommend this hotel to anyone looking to stay in saint louis we will definitely come back #21chotel#goodvibes#greatstay

Harlan M


Amazing pet friendly hotel

TripAdvisor Traveler Review Rating Reviewed 3 weeks ago

This hotel was amazing! If you need a nicer pet friendly hotel, this is the one for you! The lobby is gorgeous, as well as the rooms and amenities. Our valet Kevin was SO helpful and kind. This hotel is close to a lot of great restaurants & bars/breweries. 10/10 would recommend staying here!

Rachel C


Stay at 21C in St. Louis

TripAdvisor Traveler Review Rating Reviewed 3 weeks ago

Beautiful hotel, great service, and fabulous athletic facility! We had a great stay and would come back. The food was good and the drinks too. Conveniently located to great sites in the city and very friendly staff. Valet service was convenient too. Special shout out to Kevin at Valet!

Creston W - Los Angeles, California


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