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We recommend booking a stay with free cancellation in case your plans change.
Guest room
You have until February 27, 2025 to cancel this reservation without penalty.
Deluxe room, 1 King bed
USD $ 162 /nt
You have until February 27, 2025 to cancel this reservation without penalty.
You have until February 27, 2025 to cancel this reservation without penalty.
Deluxe room, 1 King bed
USD $ 162 /nt
You have until February 27, 2025 to cancel this reservation without penalty.
You have until February 27, 2025 to cancel this reservation without penalty.
Deluxe room, 2 Double or Full beds, 1 Queen bed
USD $ 170 /nt
You have until February 27, 2025 to cancel this reservation without penalty.
You have until February 27, 2025 to cancel this reservation without penalty.
Deluxe room, 2 Double or Full beds, 1 Queen bed
USD $ 178 /nt
You have until February 27, 2025 to cancel this reservation without penalty.
You have until February 27, 2025 to cancel this reservation without penalty.
Luxury room, 1 Double or Full bed, 1 Queen bed
USD $ 178 /nt
You have until February 27, 2025 to cancel this reservation without penalty.
You have until February 27, 2025 to cancel this reservation without penalty.
Loft, 1 Double or Full bed, 1 Queen bed
You have until February 27, 2025 to cancel this reservation without penalty.
Deluxe room, 1 King bed
You have until February 27, 2025 to cancel this reservation without penalty.
Deluxe room, 1 King bed
You have until February 27, 2025 to cancel this reservation without penalty.
Corner room, 1 King bed
You have until February 27, 2025 to cancel this reservation without penalty.
1 King bed
You have until February 27, 2025 to cancel this reservation without penalty.
Luxury room, 1 King bed
You have until February 27, 2025 to cancel this reservation without penalty.
1 King bed
You have until February 27, 2025 to cancel this reservation without penalty.
Please note, room photos and descriptions are representative of the room category. Actual rooms may vary from what is shown. Upgrades, early check-in, and late check-out are based on availability.
21c Museum Hotels reimagines a historic St. Louis fixture: the 10-story, Renaissance Revival-style YMCA building. Located in the heart of downtown St. Louis, and a short walk from the City Museum and CITYPARK stadium, 21c Museum Hotel St. Louis includes a 173-room boutique hotel, contemporary art museum, Idol Wolf restaurant, Good Press café, and Locust Street Athletic and Swim Club, a full-service wellness center. With more than 14,000 square feet of exhibition and meeting & event space seamlessly integrated into all areas of the property, there are opportunities to discover contemporary art around every corner.
21c Museum Hotel St. Louis
1528 Locust Street
Saint Louis, Missouri
63103
Nearest Airport: STL
Everything about this cool hotel was terrific: Staff, rooms, art, pool, bar! A great vibe for sure! I especially want to compliment the valets, Kevin and Dello! They were great guys and so helpful! They greeted us with a very pleasant personality and warm smile! Kudos to both of them!!
Randi M - Springfield, United States
The hotel as a whole is great. The lobby, the gallery, the bar did not disappoint. The problem we had was with the service. It started with the check in. I was traveling with three kids and I asked the person checking us in where I could find something casual for dinner within a safe walking distance and he recommended the hotel restaurant which looked great but casual or for kids. He then said “I don’t know. I haven’t lived here in 6 years.” No big deal, I have Google. When we went to our room there was a dirty room service tray right outside our door. We found a place to eat (Rosalita’s) and when we got back we ordered 4 desserts (including ice cream) from room service. They gave us one fork and one knife. I called and they brought us a bunch of plastic forks. While getting ready for bed I realized there were no face-clothes, none. The next morning when the 4 of us start showering we realize there were 2 bath towels. I called the front desk and requested 6 more and explained there were 4 of us and we were on a tight schedule for a flight. They never came. We continued to get ready using the same 2 towels. After about 30 min. I called again and eventually they brought 3 towels. When we checked out I felt like I should say something to the front desk and when I did and I got a half-hearted “sorry” and then a blank stare. He could not have cared less.
I6118JHdaniellem - Deerfield Beach, Florida
Great stay room very clean and kevin was a great valet guy the bar and food was very good and the museum was awesome we would recommend this hotel to anyone looking to stay in saint louis we will definitely come back #21chotel#goodvibes#greatstay
Harlan M
This hotel was amazing! If you need a nicer pet friendly hotel, this is the one for you! The lobby is gorgeous, as well as the rooms and amenities. Our valet Kevin was SO helpful and kind. This hotel is close to a lot of great restaurants & bars/breweries. 10/10 would recommend staying here!
Rachel C
Beautiful hotel, great service, and fabulous athletic facility! We had a great stay and would come back. The food was good and the drinks too. Conveniently located to great sites in the city and very friendly staff. Valet service was convenient too. Special shout out to Kevin at Valet!
Creston W - Los Angeles, California
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